These are the basis of most treatment regimens. There are two options: intramuscular antibiotics, classical mastitis tubes, and systemic antibiotics given intramuscularly or subcutaneously. Intermittent antibiotics should be the first-line treatment for cows with mild, uncomplicated mastitis in the same quarter. When more than a quarter are affected, systemic antibiotics should be used when the toddler changes or the cow becomes ill. Aggregate therapy, along with both systemic and intramuscular antibiotics, may increase the rate of bacteriological treatment but should only be used based on your veterinarian's advice.